Aminoglycoside phosphotransferase is a phosphotransferase that confers resistance to aminoglycoside antibiotics by catalyzing a reaction that modifies the aminoglycoside. During the reaction, a phosphate group is added to a hydroxyl group of the aminoglycoside. This renders the antibiotic ineffective so it no longer binds to the ribosomal unit during translation. Protein synthesis is thereby allowed to procede in the bacterium.
- (1990) Trower MK and Clark KG. 1990. PCR cloning of a streptomycin phosphotransferase (aphE) gene from Streptomyces griseus ATCC 12475. Nucleic Acid Res. 18:4615